Description

n-[1R,2R-(2-Methylamino)Cyclohex-1-Yl)Methyl]-N’-(1,2-Benzisothiazol-3-Yl)Piperazine Dihydrochloride is a high-purity, complex organic compound with a defined stereochemistry, serving as a critical intermediate in advanced pharmaceutical research and development. Its value lies in its role as a sophisticated building block for synthesizing novel therapeutic agents, particularly within the central nervous system (CNS) and psychiatric drug discovery pipelines. This compound is essential for research chemists and process development scientists in pharmaceutical companies and contract research organizations (CROs) focused on developing new molecular entities.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates.
• Neurological & Psychiatric Drug Discovery: Used in the synthesis of compounds targeting specific receptors within the central nervous system.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize biological activity.
• Process Chemistry & Scale-Up: Employed in route development and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in API production.
• Biochemical Research: Used in vitro studies to investigate ligand-receptor interactions and signaling pathways.

Basic Information

Product Name	n-[1R,2R-(2-Methylamino)Cyclohex-1-Yl)Methyl]-N’-(1,2-Benzisothiazol-3-Yl)Piperazine Dihydrochloride
CAS No.	1260025-93-1
Molecular Formula	C21H33Cl2N5S
Molecular Weight	466.49 g/mol
Synonyms	1-[(1R,2R)-2-(Methylamino)cyclohexyl]methyl-4-(1,2-benzisothiazol-3-yl)piperazine dihydrochloride; (1R,2R)-N-Methyl-2-[[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]methyl]cyclohexanamine dihydrochloride; 3-(4-[[(1R,2R)-2-(Methylamino)cyclohexyl]methyl]piperazin-1-yl)-1,2-benzisothiazole dihydrochloride; BTS 73,058 (dihydrochloride); BTS-73,058 dihydrochloride; BTS73058 dihydrochloride
EINECS	Contact for details

Quality Control

Our n-[1R,2R-(2-Methylamino)Cyclohex-1-Yl)Methyl]-N’-(1,2-Benzisothiazol-3-Yl)Piperazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade and cGMP standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.