Description

4-(tert-Butoxycarbonylamino)-3,3-Difluorobutanoic Acid is a high-purity, protected amino acid derivative featuring a difluoromethyl group. This compound is a critical pharmaceutical intermediate and building block for the synthesis of more complex molecules, particularly in medicinal chemistry. It is primarily used by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing new drug candidates, including protease inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting enzymatic pathways.
• Protease Inhibitor Development: Used in research and production of protease inhibitors due to its protected amino acid and difluoro motif.
• Peptidomimetics Synthesis: Serves as a crucial component for creating peptide analogs with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Employed in drug discovery programs for constructing novel molecular scaffolds with fluorine atoms to modulate potency and ADMET properties.
• Bioconjugation: The carboxylic acid and protected amine functionalities allow for selective conjugation to other molecules or solid supports.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological processes and target engagement.

Basic Information

Product Name	4-(tert-Butoxycarbonylamino)-3,3-Difluorobutanoic Acid
CAS No.	1258651-05-6
Molecular Formula	C9H15F2NO4
Molecular Weight	239.22 g/mol
Synonyms	Boc-3,3-difluoro-β-homoalanine; 3,3-Difluoro-4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid; 4-[(tert-Butoxycarbonyl)amino]-3,3-difluorobutanoic acid; N-Boc-3,3-difluoro-β-alanine; (3,3-Difluoro-4-{[(2-methyl-2-propanyl)oxy]carbonyl}amino)butanoic Acid; Boc-NH-CH(CF2)-CH2-COOH; 4-(Boc-amino)-3,3-difluorobutanoic acid
EINECS	Contact for details

Quality Control

Our 4-(tert-Butoxycarbonylamino)-3,3-Difluorobutanoic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with high-grade standards suitable for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.