Description

tert-Butyl 2-Carbamimidoylpiperidine-1-Carboxylate is a high-purity, protected guanidine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring guanidine-containing scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of guanidine-based drug candidates targeting various diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Peptidomimetic Synthesis: Employed in the construction of peptide analogs and mimetics where the guanidine group mimics arginine side chains.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in target identification and validation studies.
• Process Chemistry Development: Utilized in scaling up synthetic routes for preclinical and clinical API batches.
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents.

Basic Information

Product Name	tert-Butyl 2-Carbamimidoylpiperidine-1-Carboxylate
CAS No.	1258640-98-0
Molecular Formula	C11H21N3O2
Molecular Weight	227.31 g/mol
Synonyms	1-Boc-2-Carbamimidoylpiperidine; 1-(tert-Butoxycarbonyl)-2-carbamimidoylpiperidine; 2-Carbamimidoylpiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl N-(2-carbamimidoylpiperidin-1-yl)carbamate; 1-Boc-piperidine-2-carboxamidine; Piperidine-2-carboxamidine, 1-Boc-protected
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Carbamimidoylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.