Description

tert-Butyl 4-(2-Ethoxy-1,1-Difluoro-2-Oxoethyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and difluoro-oxoethyl ester functionality. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with potential therapeutic applications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce specific fluorinated and ester-containing motifs into drug-like molecules.
• Process Chemistry Development: Serves as a scalable intermediate for pilot plant and commercial-scale manufacturing of complex organic molecules.
• Agrochemical Synthesis: Employed in the research and development of novel crop protection agents and pesticides.
• Chemical Biology Probes: Useful for creating labeled compounds or probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	tert-Butyl 4-(2-Ethoxy-1,1-Difluoro-2-Oxoethyl)Piperidine-1-Carboxylate
CAS No.	1258639-00-7
Molecular Formula	C14H23F2NO4
Molecular Weight	307.34 g/mol
Synonyms	1-Boc-4-(2-Ethoxy-1,1-difluoro-2-oxoethyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(2-ethoxy-1,1-difluoro-2-oxoethyl)piperidine; tert-Butyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)-1-piperidinecarboxylate; 4-(2-Ethoxy-1,1-difluoro-2-oxoethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(2-Ethoxy-1,1-difluoroacetyl)piperidine; CAS 1258639-00-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Ethoxy-1,1-Difluoro-2-Oxoethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.