Description

tert-Butyl 4-(2-Ethoxy-1,1-Difluoro-2-Oxoethyl)-5,6-Dihydropyridine-1(2H)-Carboxylate CAS NO 1258637-70-5 is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoro-oxoethyl and ethoxy functional groups. This compound is of significant value for enabling complex synthetic routes in modern drug discovery, particularly for introducing fluorinated motifs that can enhance metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

This specialized intermediate serves as a critical building block in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Intermediate: Key precursor in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Fluorinated Compound Synthesis: Essential for introducing difluoroacetyl ester moieties into complex molecules to modulate their physicochemical and pharmacokinetic properties.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides where the fluorinated segment can improve activity and environmental profile.
• Chemical Biology Probes: Serves as a scaffold for creating labeled compounds and probes used in mechanistic studies and target identification.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 4-(2-Ethoxy-1,1-Difluoro-2-Oxoethyl)-5,6-Dihydropyridine-1(2H)-Carboxylate
CAS No.	1258637-70-5
Molecular Formula	C14H21F2NO4
Molecular Weight	305.32 g/mol
Synonyms	1,2,3,6-Tetrahydro-4-(2-ethoxy-1,1-difluoro-2-oxoethyl)-1-[(1,1-dimethylethoxy)carbonyl]pyridine; tert-Butyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)-1,2,3,6-tetrahydropyridine-1-carboxylate; 1-Boc-4-(2-ethoxy-1,1-difluoro-2-oxoethyl)-1,2,3,6-tetrahydropyridine; 1-(tert-Butoxycarbonyl)-4-(2-ethoxy-1,1-difluoro-2-oxoethyl)-1,2,3,6-tetrahydropyridine; 4-(2-Ethoxy-1,1-difluoro-2-oxoethyl)-1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine; 1258637-70-5; Boc-4-(2-Ethoxy-1,1-difluoro-2-oxoethyl)-1,2,3,6-tetrahydropyridine
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Quality Control

Our production of tert-Butyl 4-(2-Ethoxy-1,1-Difluoro-2-Oxoethyl)-5,6-Dihydropyridine-1(2H)-Carboxylate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing specific results for all critical parameters are provided and can be tailored to meet client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.