Description

Benzo[F][1,7]Naphthyridine-8-Propanoic Acid, 5-Amino-2-[2-[4-[2-(3,3-Difluoro-3-Phosphonopropoxy)Ethoxy]-2-Methylphenyl]Ethyl]- is a sophisticated, high-value organic intermediate characterized by a complex molecular architecture integrating naphthyridine, phosphonic acid, and fluorinated alkoxyether functionalities. This compound matters for its role as a critical building block in the development of advanced pharmaceuticals and specialty materials, where its unique structure enables precise modulation of biological activity and physicochemical properties. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors, particularly those focused on kinase inhibitor discovery, targeted drug delivery systems, and novel chelating agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other targeted therapeutic agents, especially in oncology research.
• Bioconjugation & Probe Development: Used to create fluorescent or affinity probes for biochemical assays and diagnostic applications due to its modifiable amino and phosphonate groups.
• Metal Chelation & Catalysis: Serves as a ligand or precursor for ligands in catalytic systems and metal-organic frameworks (MOFs), leveraging its phosphonate moiety.
• Advanced Material Synthesis: Incorporated into polymers or surface coatings to impart specific properties like biocompatibility, adhesion, or controlled release.
• Agrochemical Research: Investigated as an intermediate for developing new active ingredients with enhanced efficacy and environmental profiles.

Basic Information

Product Name	Benzo[F][1,7]Naphthyridine-8-Propanoic Acid, 5-Amino-2-[2-[4-[2-(3,3-Difluoro-3-Phosphonopropoxy)Ethoxy]-2-Methylphenyl]Ethyl]-
CAS No.	1258595-14-0
Molecular Formula	C29H32F2N3O6P
Molecular Weight	587.55 g/mol
Synonyms	5-Amino-2-[2-[4-[2-(3,3-difluoro-3-phosphonopropoxy)ethoxy]-2-methylphenyl]ethyl]benzo[f][1,7]naphthyridine-8-propanoic acid; BFNPA-DFPP; CAS 1258595-14-0; Amino-phosphonate naphthyridine derivative; Kinase inhibitor intermediate BFN-8PA; 1,7-Naphthyridine-8-propanoic acid derivative; Phosphonofluoropropoxy ethoxy phenyl ethyl naphthyridine
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management protocols, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Quality is verified through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.