Description

6-(4-(Trifluoromethoxy)Phenyl)Pyrazine-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture to develop novel active ingredients. It is primarily utilized in the pharmaceutical and agrochemical industries for the research and development of new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a core building block for creating novel herbicides, fungicides, and insecticides, leveraging the stability and bioactivity of the pyrazine and trifluoromethoxy motifs.
• Material Science Research: Used in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated aromatic system.
• Ligand and Catalyst Development: The carboxylic acid functionality allows for derivatization into chelating ligands for metal-organic frameworks (MOFs) or transition metal catalysts.
• Chemical Biology Probe: Employed in medicinal chemistry to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated pyrazine scaffold.

Basic Information

Product Name	6-(4-(Trifluoromethoxy)Phenyl)Pyrazine-2-Carboxylic Acid
CAS No.	1258269-13-4
Molecular Formula	C12H7F3N2O3
Molecular Weight	284.19 g/mol
Synonyms	6-[4-(Trifluoromethoxy)phenyl]pyrazine-2-carboxylic acid; 2-Pyrazinecarboxylic acid, 6-[4-(trifluoromethoxy)phenyl]-; 6-(4-Trifluoromethoxyphenyl)pyrazine-2-carboxylic acid; (6-(4-(Trifluoromethoxy)phenyl)pyrazin-2-yl)carboxylic acid
EINECS	Contact for details

Quality Control

Our 6-(4-(Trifluoromethoxy)Phenyl)Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Any single impurity	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.