Description

(R)-tert-Butyl 4-Benzyl-2-Formylpiperazine-1-Carboxylate is a high-purity chiral piperazine derivative and a crucial advanced pharmaceutical intermediate. Its value lies in its role as a key building block for synthesizing complex active pharmaceutical ingredients (APIs), particularly in chiral drug development. This compound is essential for research and manufacturing organizations in the pharmaceutical, biotechnology, and fine chemical sectors, where precise stereochemistry and reliable quality are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• API Synthesis: Serves as a key precursor in the multi-step manufacturing of complex, stereochemically-defined Active Pharmaceutical Ingredients (APIs).
• Asymmetric Catalysis Research: Used as a ligand precursor or a model substrate in developing and testing new asymmetric synthetic methodologies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for proprietary client projects requiring high-quality chiral intermediates.

Basic Information

Item	Detail
Product Name	(R)-tert-Butyl 4-Benzyl-2-Formylpiperazine-1-Carboxylate
CAS No.	1257856-16-8
Molecular Formula	C17H24N2O3
Molecular Weight	304.39 g/mol
Synonyms	(R)-1-Boc-4-Benzyl-2-formylpiperazine; (R)-tert-Butyl 4-benzyl-2-formyl-1-piperazinecarboxylate; (R)-N-Boc-4-benzyl-2-formylpiperazine; (R)-1-(tert-Butoxycarbonyl)-4-benzyl-2-formylpiperazine; (R)-Boc-4-Bn-2-CHO-piperazine; (R)-4-Benzyl-2-formylpiperazine-1-carboxylic acid tert-butyl ester; (R)-N-Boc-4-Bn-piperazine-2-carboxaldehyde
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 4-Benzyl-2-Formylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.