Description

(S)-Morpholin-3-Yl-Acetic Acid CAS NO 1257856-13-5 is a high-purity chiral building block of significant importance in modern pharmaceutical research and development. Its core value lies in providing a stereochemically defined morpholine scaffold, which is a privileged structure in medicinal chemistry for modulating the physicochemical and biological properties of drug candidates. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who are developing novel therapeutics, particularly in areas such as central nervous system (CNS) disorders, oncology, and infectious diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to introduce the morpholine pharmacophore, often to improve solubility, metabolic stability, or target binding affinity.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in the preparation of enantiomerically pure compounds for preclinical evaluation.
• Process Chemistry Development: Employed in the scale-up and route scouting for the commercial manufacturing of chiral drugs.
• Ligand and Catalyst Development: Potential use in the design of chiral ligands for asymmetric catalysis.
• Chemical Biology Probes: Incorporation into molecular probes for studying enzyme function or protein-protein interactions.

Basic Information

Item	Detail
Product Name	(S)-Morpholin-3-Yl-Acetic Acid
CAS No.	1257856-13-5
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(S)-2-(Morpholin-3-yl)acetic acid; (3S)-Morpholine-3-acetic acid; (S)-3-Morpholineacetic Acid; (S)-Morpholine-3-acetic acid; (S)-2-(3-Morpholinyl)acetic acid; (S)-Morpholinylacetic acid; (S)-3-Carboxymethylmorpholine
EINECS	Contact for details

Quality Control

Every batch of (S)-Morpholin-3-Yl-Acetic Acid is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical R&D. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with enantiomeric excess (ee) ≥98%. Specific testing includes identification (IR, NMR), assay (HPLC), chiral purity (Chiral HPLC), and control of residual solvents. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.