Description

(R)-1-Boc-4-Benzyl-2-(Hydroxymethyl)Piperazine is a high-purity, chiral piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise stereochemistry and functional group manipulation.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Utilized as a versatile scaffold and ligand precursor in catalytic asymmetric reactions to induce chirality in target molecules.
• Peptidomimetics & PROTACs: Serves as a core structural element in the design of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Agrochemical Research: Employed in the synthesis of advanced, enantiomerically pure crop protection agents and herbicides.
• Material Science: Used in the development of specialty polymers and functional materials requiring specific piperazine-based monomers.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry within university and corporate laboratories.

Basic Information

Product Name	(R)-1-Boc-4-Benzyl-2-(Hydroxymethyl)Piperazine
CAS No.	1257855-72-3
Molecular Formula	C₁₇H₂₆N₂O₃
Molecular Weight	306.40 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-4-benzyl-2-(hydroxymethyl)piperazine; (R)-N-Boc-4-Benzyl-2-(hydroxymethyl)piperazine; (R)-tert-Butyl 4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate; (R)-1-Boc-4-benzylpiperazine-2-methanol; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-benzyl-2-(hydroxymethyl)piperazine; (R)-1-Boc-4-Bn-2-HMP; BOC-(R)-4-Bn-2-HMP-Pip
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-4-Benzyl-2-(Hydroxymethyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and standard pharmacopeial tests. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with cGMP and relevant ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.