Description

2-(6-Chloro-5-Fluoro-1H-Benzimidazol-2-Yl)Pyrazine is a high-purity, advanced pharmaceutical intermediate characterized by its benzimidazole-pyrazine heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of targeted therapies. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process chemistry for oncology and antiviral applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel benzimidazole-based active pharmaceutical ingredients (APIs).
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in therapeutic areas like oncology.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for candidate drugs.
• Biochemical Research: Potential use as a molecular probe or inhibitor in enzymatic studies due to its heterocyclic scaffold.
• Custom Synthesis: Foundation for the custom manufacturing of complex, high-value specialty chemicals for advanced applications.

Basic Information

Product Name	2-(6-Chloro-5-Fluoro-1H-Benzimidazol-2-Yl)Pyrazine
CAS No.	1257535-23-1
Molecular Formula	C11H6ClFN4
Molecular Weight	248.64 g/mol
Synonyms	2-(6-Chloro-5-fluoro-1H-benzimidazol-2-yl)pyrazine; 6-Chloro-5-fluoro-2-(pyrazin-2-yl)-1H-benzimidazole; Pyrazine, 2-(6-chloro-5-fluoro-1H-benzimidazol-2-yl)-; 1257535-23-1; 2-(6-Chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)pyrazine
EINECS	Contact for details

Quality Control

Our 2-(6-Chloro-5-Fluoro-1H-Benzimidazol-2-Yl)Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.