Description

n-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-amine is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precision and reliability in building-block chemistry are paramount.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group makes it an ideal reagent for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling the formation of new carbon-carbon bonds.
• Agrochemical Research & Development: Used in creating novel herbicides, fungicides, and insecticides that leverage the pyridine and trifluoromethyl motifs for enhanced bioactivity and stability.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other advanced catalytic processes.
• Material Science & OLED Chemistry: Serves as a precursor for electron-transport materials, host materials, and other functional components in organic light-emitting diodes (OLEDs) and electronic devices.
• Chemical Biology & Probe Synthesis: Utilized to create molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	n-Ethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Pyridin-2-Amine
CAS No.	1257432-06-6
Molecular Formula	C14H20BF3N2O2
Molecular Weight	316.13 g/mol
Synonyms	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine, N-ethyl derivative; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)-2-(ethylamino)pyridine; 2-(Ethylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine; N-Ethyl-3-trifluoromethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; Boronic acid, B-[2-(ethylamino)-3-(trifluoromethyl)-4-pyridinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; CAS 1257432-06-6
EINECS	Contact for details

Quality Control

Our n-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.