Description

2-[4-(Bromomethyl)Phenyl]-5-Fluoropyridine is a high-value brominated fluoropyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both a reactive bromomethyl handle and a fluoropyridine core, makes it indispensable for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atom and aromatic system enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Building block for the synthesis of organic electronic materials, such as charge-transport layers or fluorinated liquid crystals.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological processes due to its derivatizable bromomethyl group.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.

Basic Information

Product Name	2-[4-(Bromomethyl)Phenyl]-5-Fluoropyridine
CAS No.	1257426-56-4
Molecular Formula	C12H9BrFN
Molecular Weight	266.11 g/mol
Synonyms	5-Fluoro-2-[4-(bromomethyl)phenyl]pyridine; 4-(5-Fluoropyridin-2-yl)benzyl Bromide; 2-(4-(Bromomethyl)phenyl)-5-fluoropyridine; [4-(5-Fluoropyridin-2-yl)phenyl]methyl Bromide; 5-Fluoro-2-(4-(bromomethyl)phenyl)pyridine; 2-(4-Bromomethylphenyl)-5-fluoropyridine
EINECS	Contact for details

Quality Control

Our 2-[4-(Bromomethyl)Phenyl]-5-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.