Description

6-Bromo-3-Chloropyrazine-2-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced chemical synthesis. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides due to its bioactive pyrazine core.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for sequential Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution: The cyano group and halogen atoms provide multiple sites for nucleophilic attack, enabling diverse derivatization.
• Library Synthesis: Employed in high-throughput and combinatorial chemistry for generating focused libraries of heterocyclic compounds for biological screening.

Basic Information

Product Name	6-Bromo-3-Chloropyrazine-2-Carbonitrile
CAS No.	1257072-34-6
Molecular Formula	C5H1BrClN3
Molecular Weight	218.43 g/mol
Synonyms	3-Chloro-6-bromopyrazine-2-carbonitrile; 2-Cyano-3-chloro-6-bromopyrazine; 6-Bromo-3-chloro-2-pyrazinecarbonitrile; 2-Pyrazinecarbonitrile, 6-bromo-3-chloro-; Bromochloropyrazinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-3-Chloropyrazine-2-Carbonitrile is manufactured under strict quality management systems. We guarantee high-purity material suitable for demanding research and scale-up applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC/GC purity data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.