Description

(7S,8As)-7-Amino-2-Methylhexahydropyrrolo[1,2-A]Pyrazine-1,4-Dione(Saltdata: Free) CAS NO 1256636-30-2 is a high-purity, non-salt form pyrrolopyrazine-dione derivative, a sophisticated chiral building block critical for advanced pharmaceutical synthesis. Its value lies in providing a defined stereochemical scaffold essential for developing novel active pharmaceutical ingredients (APIs) with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, especially protease inhibitors.
• Medicinal Chemistry Research: Used as a constrained scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptidomimetic Development: Acts as a core structure for designing and synthesizing peptidomimetics that mimic natural peptides but with enhanced metabolic stability.
• API Synthesis: Incorporated into the synthetic route of complex target molecules during process development and scale-up for clinical trials.
• Biochemical Probe Synthesis: Utilized to create specialized chemical probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(7S,8As)-7-Amino-2-Methylhexahydropyrrolo[1,2-A]Pyrazine-1,4-Dione(Saltdata: Free)
CAS No.	1256636-30-2
Molecular Formula	C8H13N3O2
Molecular Weight	183.21 g/mol
Synonyms	(7S,8aS)-7-Amino-2-methylhexahydro-1H-pyrrolo[1,2-a]pyrazine-1,4-dione; (7S,8aS)-7-Amino-2-methyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione; 7-Amino-2-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione; (7S,8aS)-7-Amino-2-methyl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazine; Pyrrolo[1,2-a]pyrazine-1,4-dione, 7-amino-2-methylhexahydro-, (7S,8aS)-; (7S,8aS)-7-Amino-2-methylhexahydro-1H-pyrrolo[1,2-a]pyrazine-1,4-dione (Free base).
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Quality Control

Our (7S,8As)-7-Amino-2-Methylhexahydropyrrolo[1,2-A]Pyrazine-1,4-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with ICH guidelines for impurities, and specifications can be aligned with customer requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.