Description

(7S,8As)-7-Aminohexahydropyrrolo[1,2-A]Pyrazine-1,4-Dione (Saltdata: Free) is a high-purity, non-salt form chiral building block and advanced pharmaceutical intermediate. Its value lies in its unique fused pyrrolopyrazine-dione scaffold, which is critical for synthesizing complex molecules with specific stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly for creating novel active pharmaceutical ingredients (APIs) and investigating new therapeutic modalities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel APIs, especially in oncology, neurology, and anti-infective drug discovery.
• Peptidomimetic Research: Serves as a constrained, heterocyclic scaffold to mimic peptide secondary structures, aiding in the design of more stable and bioavailable drug candidates.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space and improve drug-like properties.
• Asymmetric Synthesis: Employed as a building block in stereoselective synthesis to introduce complex molecular architectures with high enantiomeric purity.
• Bioconjugation & Probe Development: The primary amine functionality allows for conjugation to labels, tags, or other biomolecules for chemical biology applications.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and process development.

Basic Information

Product Name	(7S,8As)-7-Aminohexahydropyrrolo[1,2-A]Pyrazine-1,4-Dione (Saltdata: Free)
CAS No.	1256636-27-7
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	(7S,8aS)-7-Aminohexahydropyrrolo[1,2-a]pyrazine-1,4-dione; 7-Aminohexahydropyrrolo[1,2-a]pyrazine-1,4-dione; (7S,8aS)-7-Amino-1,2,3,6,7,8-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione; Pyrrolo[1,2-a]pyrazine-1,4-dione, 7-aminohexahydro-, (7S,8aS)-; (7S,8aS)-7-Aminooctahydropyrrolo[1,2-a]pyrazine-1,4-dione; CAS 1256636-27-7.
EINECS	Contact for details

Quality Control

Our (7S,8As)-7-Aminohexahydropyrrolo[1,2-A]Pyrazine-1,4-Dione is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.