Description

4-[(4-Trifluoromethyl)Phenyl]-Pyridine-2-Carboxylic Acid is a high-value, multi-functional organic building block characterized by its pyridine-carboxylic acid core and a trifluoromethylphenyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides, where the trifluoromethyl group contributes to biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for constructing complex chelating ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers.
• Chemical Biology Probes: Utilized to develop fluorescent tags or molecular probes for studying biological processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical production.

Basic Information

Product Name	4-[(4-Trifluoromethyl)Phenyl]-Pyridine-2-Carboxylic Acid
CAS No.	1255634-46-8
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	2-Pyridinecarboxylic acid, 4-[4-(trifluoromethyl)phenyl]-; 4-(4-(Trifluoromethyl)phenyl)picolinic acid; 4-(α,α,α-Trifluoro-p-tolyl)picolinic acid; 4-(4-Trifluoromethylphenyl)pyridine-2-carboxylic acid; 4-(4-Trifluoromethylphenyl)-2-pyridinecarboxylic acid; 1255634-46-8; 4-(4-Trifluoromethylphenyl)picolinic acid
EINECS	Contact for details

Quality Control

Our 4-[(4-Trifluoromethyl)Phenyl]-Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and quality assurance for your projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.