Description

6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyrazine Hydrochloride is a high-purity heterocyclic building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing novel chemical libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Potential application as a building block for developing new crop protection agents and herbicides.
• Material Science: Investigated for use in the synthesis of advanced organic electronic materials and ligands for catalysis.

Basic Information

Product Name	6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyrazine Hydrochloride
CAS No.	1255099-34-3
Molecular Formula	C6H8N3·HCl
Molecular Weight	157.61 g/mol (Free base: 122.15 g/mol)
Synonyms	5H-Pyrrolo[3,4-b]pyrazine, 6,7-dihydro-, hydrochloride; 6,7-Dihydro-5H-pyrrolo[3,4-b]pyrazine HCl; Pyrrolo[3,4-b]pyrazine, 6,7-dihydro-5H-, hydrochloride; 1255099-34-3; CAS 1255099-34-3
EINECS	Contact for details

Quality Control

Our 6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyrazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.