Description

1-(3-Pyridinyl)-3-(Trifluoromethyl)-1H-Pyrazole-5-Carbonitrile is a high-value heterocyclic building block featuring a pyridine and a pyrazole core with a trifluoromethyl and nitrile functional group. This compound is critical for medicinal chemistry and agrochemical research, enabling the synthesis of novel molecules with enhanced biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and crop protection industries for lead optimization and the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small-molecule drug candidates, particularly in kinase inhibitor and central nervous system (CNS) targeted therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for improved lipophilicity and bioavailability.
• Material Science Precursor: Serves as a building block for advanced organic materials, including ligands for catalysis and components for organic electronics.
• Chemical Biology Probe: Utilized in the design and synthesis of chemical probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up activities.

Basic Information

Product Name	1-(3-Pyridinyl)-3-(Trifluoromethyl)-1H-Pyrazole-5-Carbonitrile
CAS No.	1255041-97-4
Molecular Formula	C10H5F3N4
Molecular Weight	238.17 g/mol
Synonyms	3-(Trifluoromethyl)-1-(pyridin-3-yl)-1H-pyrazole-5-carbonitrile; 1-(3-Pyridyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile; 1-(Pyridin-3-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile; 5-Cyano-1-(3-pyridyl)-3-(trifluoromethyl)pyrazole; 3-Trifluoromethyl-1-(3-pyridinyl)-1H-pyrazole-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 1-(3-Pyridinyl)-3-(Trifluoromethyl)-1H-Pyrazole-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming the product meets your specified research or development grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.