Description

Ly 2874455 is a potent and selective small molecule inhibitor of fibroblast growth factor receptors (FGFRs). This compound is a critical research tool for investigating the role of FGFR signaling pathways in cellular proliferation, differentiation, and survival. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology and developmental biology. The product, identified by CAS No. 1254473-64-7, is supplied as a high-purity biochemical for preclinical studies.

Application

• Biochemical Research: Used as a selective FGFR inhibitor to study receptor tyrosine kinase signaling mechanisms and downstream effects.
• Oncology Research: Investigated in preclinical models for its potential anti-tumor activity against cancers driven by FGFR amplification or mutation, such as certain breast, lung, and bladder cancers.
• Cell Biology Studies: Employed to modulate FGFR activity in cell culture to understand its role in cell growth, migration, and angiogenesis.
• Drug Discovery & Development: Serves as a reference compound or a starting point for the design and synthesis of novel FGFR-targeted therapeutic agents.
• Signal Transduction Pathway Analysis: A key reagent for dissecting the FGF/FGFR pathway and its crosstalk with other cellular signaling networks.

Basic Information

Product Name	Ly 2874455
CAS No.	1254473-64-7
Molecular Formula	C₂₃H₂₀N₆O₂
Molecular Weight	412.45 g/mol
Synonyms	LY2874455; N-[3-[5-Chloro-2-[[(3S)-3-(methylamino)-1-pyrrolidinyl]carbonyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]acetamide; FGFR Inhibitor (LY2874455); 5-Acetamido-3-(5-chloro-2-((S)-3-(methylamino)pyrrolidine-1-carbonyl)phenyl)-1H-pyrrolo[2,3-b]pyridine; Pan-FGFR Inhibitor LY2874455
EINECS	Contact for details

Quality Control

Our Ly 2874455 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep desiccated at -20°C. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.