Description

5-Bromo-3-(difluoromethyl)-2-methoxypyridine is a high-value, multi-functional pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogenated and fluorinated structure makes it an indispensable intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific bromine and difluoromethyl motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis due to the electron-withdrawing and steric properties of its substituents.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials that require specific halogenated aromatic cores.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	5-Bromo-3-(difluoromethyl)-2-methoxypyridine
CAS No.	1254123-51-7
Molecular Formula	C7H6BrF2NO
Molecular Weight	238.03 g/mol
Synonyms	2-Methoxy-5-bromo-3-(difluoromethyl)pyridine; 3-(Difluoromethyl)-5-bromo-2-methoxypyridine; 5-Bromo-3-difluoromethyl-2-methoxypyridine; Pyridine, 5-bromo-3-(difluoromethyl)-2-methoxy-; 1254123-51-7
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-3-(difluoromethyl)-2-methoxypyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.