Description

tert-Butyl 2-(Trifluoromethyl)Pyridin-3-Ylcarbamate is a high-value, protected pyridine derivative featuring a trifluoromethyl group and a tert-butyl carbamate moiety. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Organic Synthesis Building Block: The tert-butyloxycarbonyl (Boc) protecting group allows for selective reactions, making it valuable for constructing complex heterocyclic molecules in medicinal chemistry.
• Material Science Research: Employed in the development of specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis manufacturers for client-directed projects and scale-up activities.

Basic Information

Product Name	tert-Butyl 2-(Trifluoromethyl)Pyridin-3-Ylcarbamate
CAS No.	1253654-52-2
Molecular Formula	C11H13F3N2O2
Molecular Weight	262.23 g/mol
Synonyms	3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)pyridin-3-amine, N-Boc-protected; tert-Butyl N-[2-(trifluoromethyl)pyridin-3-yl]carbamate; 3-(Boc-amino)-2-(trifluoromethyl)pyridine; Boc-3-amino-2-trifluoromethylpyridine; 2-Trifluoromethyl-3-pyridylcarbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 2-(Trifluoromethyl)Pyridin-3-Ylcarbamate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality management system is designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.