Description

Ethyl 3-(Trifluoromethyl)Pyrazine-2-Carboxylate is a high-value fluorinated pyrazine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a carboxylate ester and a trifluoromethyl group, makes it an essential intermediate for creating compounds with enhanced biological activity and physicochemical properties. This product is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing specialty materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Ligand and Catalyst Development: Serves as a precursor for constructing complex nitrogen-containing heterocyclic ligands used in catalysis and material science.
• Fine Chemical Production: Employed in the custom synthesis of fluorinated specialty chemicals for electronics, imaging, and other high-tech applications.
• Academic and Contract Research: A valuable reagent for university laboratories and CROs (Contract Research Organizations) exploring new chemical spaces and structure-activity relationships.

Basic Information

Product Name	Ethyl 3-(Trifluoromethyl)Pyrazine-2-Carboxylate
CAS No.	1253196-13-2
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	Ethyl 3-(trifluoromethyl)pyrazine-2-carboxylate; 2-Pyrazinecarboxylic acid, 3-(trifluoromethyl)-, ethyl ester; Ethyl 3-trifluoromethylpyrazine-2-carboxylate; 3-Trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester; ETFC; 1253196-13-2
EINECS	Contact for details

Quality Control

Our Ethyl 3-(Trifluoromethyl)Pyrazine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong alkalis and sources of fluoride ions. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.