Description

2-Amino-3-Chloro-5-Iodopyrazine is a high-purity halogenated pyrazine derivative, a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring amino, chloro, and iodo substituents, makes it an indispensable intermediate for constructing complex heterocyclic systems. This compound is primarily utilized by pharmaceutical R&D and agrochemical manufacturers for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyrazine core.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic semiconductors.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse biaryl structures.
• Ligand Synthesis: Used to prepare specialized nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Amino-3-Chloro-5-Iodopyrazine
CAS No.	1252597-70-8
Molecular Formula	C4H3ClIN3
Molecular Weight	255.44 g/mol
Synonyms	3-Chloro-5-iodopyrazin-2-amine; 5-Iodo-3-chloropyrazin-2-amine; 2-Amino-3-chloro-5-iodopyrazine; 3-Chloro-5-iodo-2-pyrazinamine; 2-Pyrazinamine, 3-chloro-5-iodo-; 1252597-70-8; 3-Chloro-5-iodo-2-aminopyrazine
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Chloro-5-Iodopyrazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.