Description

(R)-4-n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl CAS NO 1251903-83-9 is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound is essential for pharmaceutical research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs) with specific stereochemical requirements. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, especially those targeting neurological and oncological pathways.
• Peptidomimetic Research: Serves as a constrained scaffold in the design and development of peptide mimics to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure compounds for clinical candidates and high-value fine chemicals.
• Chemical Biology Probes: Employed in the construction of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds under cGMP.

Basic Information

Product Name	(R)-4-n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	1251903-83-9
Molecular Formula	C12H23ClN2O4
Molecular Weight	294.78 g/mol
Synonyms	(R)-Methyl 4-(tert-butoxycarbonyl)piperazine-2-carboxylate hydrochloride; (R)-1-Boc-piperazine-2-carboxylic acid methyl ester hydrochloride; (R)-4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid methyl ester HCl; (R)-N-Boc-piperazine-2-carboxylic acid methyl ester hydrochloride; (R)-1-tert-Butyl 2-methyl 4-oxopiperazine-1,2-dicarboxylate hydrochloride; (R)-Boc-Pip-OMe·HCl; (R)-Boc-Piperazine-2-COOMe·HCl
EINECS	Contact for details

Quality Control

Our (R)-4-n-Boc-Piperazine-2-Carboxylic Acid Methyl Ester-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (nitrogen or argon) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.