Description

cis-tert-Butyl 8-Bromo-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate CAS NO 1251021-97-2 is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic indole scaffold. This compound is critically important for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of central nervous system (CNS) agents, receptor modulators, and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the tetrahydro-pyridoindole core.
• API Development: Employed in the development and scale-up processes for new Active Pharmaceutical Ingredients (APIs) with potential antipsychotic, antidepressant, or anxiolytic activity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation in preclinical research.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client-sponsored drug discovery programs.
• Academic Research: Used in university and institutional laboratories for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	cis-tert-Butyl 8-Bromo-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate
CAS No.	1251021-97-2
Molecular Formula	C19H23BrN2O2
Molecular Weight	391.30 g/mol
Synonyms	8-Bromo-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; tert-Butyl 8-bromo-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylate; cis-8-Bromo-2-(tert-butoxycarbonyl)-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole; (cis)-tert-Butyl 8-bromo-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate; BOC-protected 8-bromo-tetrahydro-pyridoindole; 8-Bromo-THPI-Boc; 1251021-97-2.
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl 8-Bromo-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.