Description

cis-tert-Butyl8-Fluoro-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a fluorine atom and a tert-butyloxycarbonyl (Boc) protecting group. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly within the central nervous system (CNS) and oncology fields. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new pharmacophores.
• API (Active Pharmaceutical Ingredient) Development: Serves as a critical precursor in the development and scale-up of potential new active substances.
• CNS Drug Discovery: Its structural features make it relevant for research into treatments for conditions like depression, anxiety, and neurodegenerative diseases.
• Oncological Research: Employed in the synthesis of compounds being investigated for anti-cancer properties.
• Process Chemistry & Scale-Up: Used by chemical development teams to establish robust and efficient synthetic routes from laboratory to pilot plant scale.
• Academic Research: Utilized in university and institutional labs for advanced studies in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	cis-tert-Butyl8-Fluoro-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate
CAS No.	1251015-03-8
Molecular Formula	C16H21FN2O2
Molecular Weight	292.35 g/mol
Synonyms	8-Fluoro-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; tert-Butyl 8-fluoro-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate; cis-Boc-8-fluoro-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indole; 1251015-03-8; 8-Fluoro-1,2,3,4,4a,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; (cis)-tert-Butyl 8-fluoro-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl8-Fluoro-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with consistent quality that meets the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption. Recommended long-term storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.