Description

Racemic Endo-7-Aza-Bicyclo[2.2.1]Heptane -2,7-Dicarboxylic Acid 7-tert-Butyl Ester 2-Ethyl Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a rigid, functionalized bicyclic scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of neurologically active compounds and protease inhibitors.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, especially those requiring a constrained azabicyclic structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Neurological Drug Development: Core scaffold for developing ligands targeting nicotinic acetylcholine receptors (nAChRs) and other neurological targets.
• Protease Inhibitor Synthesis: Serves as a precursor in the creation of inhibitors for various enzymes, including renin and HIV protease.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Asymmetric Synthesis: The racemic mixture can be used as a starting point for chiral resolution to obtain enantiomerically pure intermediates.

Basic Information

Product Name	Racemic Endo-7-Aza-Bicyclo[2.2.1]Heptane -2,7-Dicarboxylic Acid 7-tert-Butyl Ester 2-Ethyl Ester Hydrochloride
CAS No.	1251009-93-4
Molecular Formula	C15H26ClNO4
Molecular Weight	319.82 g/mol
Synonyms	7-Azabicyclo[2.2.1]heptane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) 2-ethyl ester, endo-, hydrochloride (1:1); (±)-endo-2-(Ethoxycarbonyl)-7-[(tert-butoxy)carbonyl]-7-azabicyclo[2.2.1]heptane hydrochloride; endo-7-tert-Butyl 2-ethyl 7-azabicyclo[2.2.1]heptane-2,7-dicarboxylate hydrochloride; 7-N-Boc-2-ethoxycarbonyl-7-azabicyclo[2.2.1]heptane hydrochloride (racemic endo); Bicyclo[2.2.1]heptane-2,7-dicarboxylic acid, 7-aza-, 7-(1,1-dimethylethyl) 2-ethyl ester, hydrochloride, endo- (±)-; AZD-1 Building Block Hydrochloride (related); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. The material is characterized and released according to comprehensive in-house specifications, which typically include identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A Certificate of Analysis (COA) detailing lot-specific results is provided with each shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.