Description

6-Boc-3A,4,5,6,7,7A-Hexahydroisoxazolo-[5,4-C]Pyridine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex, conformationally constrained bicyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and anti-infective drug discovery.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The fused isoxazolo-pyridine structure is valuable for designing inhibitors targeting various protease enzymes.
• Peptidomimetic Synthesis: Serves as a constrained, non-peptide backbone mimic for creating stable and bioavailable peptide analogs.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for investigating biological pathways and target validation.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of target molecules.

Basic Information

Item	Information
Product Name	6-Boc-3A,4,5,6,7,7A-Hexahydroisoxazolo-[5,4-C]Pyridine-3-Carboxylic Acid
CAS No.	1251003-08-3
Molecular Formula	C13H18N2O5
Molecular Weight	282.29 g/mol
Synonyms	tert-Butyl 3-carboxy-3a,4,5,6,7,7a-hexahydroisoxazolo[5,4-c]pyridine-6-carboxylate; 6-(tert-Butoxycarbonyl)-3a,4,5,6,7,7a-hexahydroisoxazolo[5,4-c]pyridine-3-carboxylic acid; Bicyclic Isoxazolidine-Pyridine Carboxylic Acid Derivative; Boc-Hexahydroisoxazolopyridine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 6-Boc-3A,4,5,6,7,7A-Hexahydroisoxazolo-[5,4-C]Pyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.