Description

tert-Butyl 3-Bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate is a high-value, heterocyclic building block featuring a reactive bromine atom and a protected amine, making it a versatile intermediate for targeted molecular synthesis. This compound matters because it enables the efficient construction of complex pharmacophores, particularly in the development of kinase inhibitors and other small molecule therapeutics. Pharmaceutical R&D and agrochemical innovators need this precise chemical scaffold to accelerate their discovery pipelines and create novel bioactive compounds with improved properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of kinase inhibitors, particularly those targeting oncology and inflammatory disease pathways.
• Medicinal Chemistry: Used in parallel and combinatorial library synthesis for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Agrochemical Research: Serves as a building block for developing novel active ingredients with herbicidal or fungicidal activity.
• Chemical Biology: Employed in the creation of molecular probes and tool compounds for studying enzyme function and cellular signaling.
• Peptidomimetics: The triazolopyrazine core can be utilized to design and synthesize conformationally constrained peptide analogs.
• Material Science: Potential precursor for nitrogen-rich heterocyclic compounds used in specialty polymers or ligands for catalysis.

Basic Information

Product Name	tert-Butyl 3-Bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate
CAS No.	1251002-97-7
Molecular Formula	C10H13BrN4O2
Molecular Weight	301.14 g/mol
Synonyms	5-[(tert-Butoxy)carbonyl]-3-bromo-4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazine; 3-Bromo-5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazine; tert-Butyl 3-bromo-4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate; Boc-3-Bromo-4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazine; 3-Bromo-6,7-dihydro-5H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester; 3-Bromo-5-Boc-4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazine; 1251002-97-7
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 3-Bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed under an inert atmosphere if prolonged storage is anticipated to minimize potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.