Description

3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex fused heterocyclic structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring sophisticated nitrogen-containing scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the construction of complex molecules for potential use as active pharmaceutical ingredients, leveraging its triazolopyrazine core.
• Chemical Biology Probes: Serves as a starting material for creating specialized probes used to study biological pathways and enzyme functions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for advanced studies in heterocyclic chemistry and synthetic methodology development.

Basic Information

Product Name	3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid tert-Butyl Ester
CAS No.	1251002-77-3
Molecular Formula	C12H18N4O3
Molecular Weight	266.30 g/mol
Synonyms	tert-Butyl 3-(hydroxymethyl)-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate; 8H-[1,2,4]Triazolo[4,3-a]pyrazine-7-carboxylic acid, 5,6-dihydro-3-(hydroxymethyl)-, 1,1-dimethylethyl ester; 3-Hydroxymethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester; 1251002-77-3; UNII-7Q5J6QVF1C; 7Q5J6QVF1C; BCP31963; tert-butyl 3-(hydroxymethyl)-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate
EINECS	Contact for details

Quality Control

Our 3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.