Description

3-Hydroxymethyl-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid tert-Butyl Ester (Wx140081) is a high-purity, advanced pharmaceutical intermediate featuring a fused triazolopyrazine heterocyclic core. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with potential biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Synthesis: The hydroxymethyl group provides a handle for further functionalization, useful in creating chemical probes for biological assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines for global clients.

Basic Information

Product Name	3-Hydroxymethyl-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid tert-Butyl Ester (Wx140081)
CAS No.	1251002-72-8
Molecular Formula	C12H18N4O3
Molecular Weight	266.30 g/mol
Synonyms	tert-Butyl 3-(hydroxymethyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate; WX-140081; 3-(Hydroxymethyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 3-(hydroxymethyl)-6,7-dihydro-4H-[1,2,3]triazolo[1,5-a]pyrazine-5-carboxylate; BOC-protected triazolopyrazine intermediate
EINECS	Contact for details

Quality Control

Our 3-Hydroxymethyl-6,7-Dihydro-4H-[1,2,3]Triazolo[1,5-A]Pyrazine-5-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.