Description

(3Ar,4R,7As)-tert-Butyl 4-(tert-Butoxycarbonylamino)Hexahydro-1H-Isoindole-2(3H)-Carboxylate is a sophisticated chiral building block and advanced pharmaceutical intermediate. This compound is of critical importance for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of peptidomimetics, constrained peptides, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Peptidomimetics Synthesis: Used in constructing conformationally restricted peptide analogs to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Asymmetric Synthesis: Employed in stereoselective synthesis due to its defined (3Ar,4R,7As) stereochemistry.
• Protease Inhibitor Development: Potential building block for inhibitors targeting specific enzymatic pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(3Ar,4R,7As)-tert-Butyl 4-(tert-Butoxycarbonylamino)Hexahydro-1H-Isoindole-2(3H)-Carboxylate
CAS No.	1251001-17-8
Molecular Formula	C18H32N2O4
Molecular Weight	340.46 g/mol
Synonyms	tert-Butyl 4-[(tert-butoxycarbonyl)amino]hexahydro-1H-isoindole-2(3H)-carboxylate; (3aR,4R,7aS)-2-Boc-4-(Boc-amino)octahydroisoindole; 1H-Isoindole-2(3H)-carboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-, 1,1-dimethylethyl ester, (3aR,4R,7aS)-; Boc-4-(Boc-NH)-hexahydroisoindoline; (3aR,4R,7aS)-Boc-4-(Boc-amino)perhydroisoindole; 2-Boc-4-(Boc-amino)octahydroisoindole; Chiral Isoindoline Boc Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, GC, and NMR to guarantee identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. Our quality management system supports the needs of GMP (Good Manufacturing Practice) environments for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere such as nitrogen or argon after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.