Description

3-Hydroxymethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester is a high-purity, advanced pharmaceutical intermediate (API intermediate) with the CAS number 1250998-91-4. This compound is a critical building block in modern medicinal chemistry, valued for its fused heterocyclic pyrazolopyridine core which is instrumental in the synthesis of bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing complex molecules targeting various biological pathways.
• CNS Drug Development: Used in the synthesis of compounds being investigated for neurological and psychiatric disorders.
• Oncology Research: Employed as a building block for potential kinase inhibitors and other anti-cancer agents.
• Chemical Biology: Utilized in the design of molecular probes to study enzyme function and protein interactions.
• Process Chemistry & Scale-Up: Serves as a critical intermediate during the optimization and commercial scale-up of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-Hydroxymethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester
CAS No.	1250998-91-4
Molecular Formula	C13H19N3O3
Molecular Weight	265.31 g/mol
Synonyms	tert-Butyl 3-(hydroxymethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate; 1,4,6,7-Tetrahydro-3-(hydroxymethyl)-5H-pyrazolo[4,3-c]pyridine-5-carboxylic Acid 1,1-Dimethylethyl Ester; 5-tert-Butoxycarbonyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-3-carbaldehyde (reduction product); Pyrazolopyridine tert-butyl ester intermediate; CAS 1250998-91-4
EINECS	Contact for details

Quality Control

Our production of 3-Hydroxymethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide detailed Certificates of Analysis (COA) to ensure traceability and compliance with your research or cGMP starting material requirements, supporting robust regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.