Description

tert-Butyl 2-Bromo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrazolopyrazine core. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex heterocyclic scaffolds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly for kinase-targeted therapies and other small molecule drugs. The product is supplied with a Certificate of Analysis to ensure batch-to-batch consistency and reliability for sensitive synthesis workflows.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing and screening novel compound libraries in drug discovery programs.
• Kinase Inhibitor Development: Serves as a core structural element in the design of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme function and cellular signaling pathways.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the efficient, large-scale production of candidate drugs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the global pharmaceutical pipeline from discovery to commercial manufacturing.

Basic Information

Product Name	tert-Butyl 2-Bromo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate
CAS No.	1250998-21-0
Molecular Formula	C12H16BrN3O2
Molecular Weight	314.18 g/mol
Synonyms	2-Bromo-5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine; tert-Butyl 2-bromo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylate; 2-Bromo-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester; 1250998-21-0; 2-Bromo-5-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine; 2-Bromo-5-Boc-6,7-dihydropyrazolo[1,5-a]pyrazine; 2-Bromo-5-N-Boc-6,7-dihydropyrazolo[1,5-a]pyrazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Bromo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.