Description

cis-tert-Butyl8-Chloro-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS number 1250994-53-6. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its precise stereochemistry and functional group compatibility. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and oncology research fields.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for developing new therapeutic molecules.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and novel synthetic methodologies.
• Reference Standard: Can be used as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Product Name	cis-tert-Butyl8-Chloro-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate
CAS No.	1250994-53-6
Molecular Formula	C16H19ClN2O2
Molecular Weight	306.79 g/mol
Synonyms	tert-Butyl (3aR,9bS)-8-chloro-2,3,3a,4-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate; (3aR,9bS)-8-Chloro-2,3,3a,4-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; cis-8-Chloro-1,2,3,4-tetrahydro-2-(tert-butoxycarbonyl)pyrido[4,3-b]indole; BOC-protected 8-chlorotetrahydro-β-carboline derivative; 1250994-53-6; tert-Butyl 8-chloro-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate
EINECS	Contact for details

Quality Control

Our cis-tert-Butyl8-Chloro-3,4,4A,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-2(9Bh)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with the standards expected for pharmaceutical development, supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.