Description

Racemic-(2R,3As,7Ar)-1-Benzyl 5-tert-Butyl 2-(Aminomethyl)Hexahydro-1H-Pyrrolo[3,2-C]Pyridine-1,5(6H)-Dicarboxylate (Wx110492) is a complex, multi-functional chiral pyrrolopyridine derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its intricate fused bicyclic structure with protected amine and carboxylate groups makes it invaluable for constructing sophisticated molecular architectures. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in the areas of neurology and oncology.

Application

• Key Intermediate in Drug Discovery & Development: Serves as a core scaffold for synthesizing novel bioactive molecules targeting G-protein-coupled receptors (GPCRs) and enzymes.
• Pharmaceutical Active Ingredient (API) Synthesis: Used in the multi-step synthesis of potential drug candidates, especially those requiring a rigid, polycyclic amine framework.
• Asymmetric Catalysis & Chiral Pool Building Block: The racemic mixture provides a source of chiral centers for further resolution and use in stereoselective synthesis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Peptidomimetic & Constrained Analogue Design: Its structure is ideal for mimicking peptide turn motifs, useful in designing metabolically stable drug analogues.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical pipelines with custom synthetic chemistry.

Basic Information

Item	Detail
Product Name	Racemic-(2R,3As,7Ar)-1-Benzyl 5-tert-Butyl 2-(Aminomethyl)Hexahydro-1H-Pyrrolo[3,2-C]Pyridine-1,5(6H)-Dicarboxylate (Wx110492)
CAS No.	1250993-13-5
Molecular Formula	C22H33N3O4
Molecular Weight	403.52 g/mol
Synonyms	1,5(6H)-Dicarboxylic acid, 2-(aminomethyl)hexahydro-1H-pyrrolo[3,2-c]pyridine-, 1-(phenylmethyl) 5-(1,1-dimethylethyl) ester, (2R,3aS,7aR)-rel-; Wx110492; 1-Benzyl 5-tert-butyl 2-(aminomethyl)hexahydro-1H-pyrrolo[3,2-c]pyridine-1,5-dicarboxylate; rel-(2R,3aS,7aR)-1-Benzyl 5-tert-butyl 2-(aminomethyl)hexahydro-1H-pyrrolo[3,2-c]pyridine-1,5-dicarboxylate; tert-Butyl 2-(aminomethyl)-1-(benzyloxycarbonyl)hexahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate; Pyrrolopyridine derivative Wx110492.
EINECS	Contact for details

Quality Control

Our Racemic-(2R,3As,7Ar)-1-Benzyl 5-tert-Butyl 2-(Aminomethyl)Hexahydro-1H-Pyrrolo[3,2-C]Pyridine-1,5(6H)-Dicarboxylate (Wx110492) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements. Specifications are aligned with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Racemic mixture (50:50)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.