Description

1-(5-Fluoropyridin-3-Ylsulfonyl)Piperazine is a high-purity, functionalized piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key sulfonamide intermediate, enabling the development of novel molecules with targeted biological activity. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients, particularly in medicinal chemistry programs focused on kinase inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in oncology and CNS therapeutic areas.
• Kinase Inhibitor Scaffold: Used in the synthesis of potential kinase inhibitors due to the sulfonamide and fluoropyridine motifs.
• Agrochemical Research: Serves as a building block for novel active ingredients in crop protection and pesticide development.
• Chemical Biology Probe Synthesis: Utilized in creating molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D pipelines.
• Academic Research: Used in university and institutional labs for methodological studies in heterocyclic and sulfonamide chemistry.

Basic Information

Product Name	1-(5-Fluoropyridin-3-Ylsulfonyl)Piperazine
CAS No.	1250952-19-2
Molecular Formula	C9H12FN3O2S
Molecular Weight	245.27 g/mol
Synonyms	1-[(5-Fluoropyridin-3-yl)sulfonyl]piperazine; 3-(Piperazine-1-sulfonyl)-5-fluoropyridine; 5-Fluoro-3-(piperazine-1-sulfonyl)pyridine; 5-Fluoro-3-piperazin-1-ylsulfonylpyridine; 1-(5-Fluoro-3-pyridylsulfonyl)piperazine; 1-(5-Fluoropyridine-3-sulfonyl)piperazine; Piperazine, 1-[(5-fluoro-3-pyridinyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our 1-(5-Fluoropyridin-3-Ylsulfonyl)Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. For custom synthesis projects, we adhere to cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.