Description

1-(5-Fluoropyridin-3-Ylsulfonyl)Pyrrolidin-2-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfonamide-linked pyrrolidine-pyridine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, especially within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Protease Inhibitor Development: The sulfonamide-pyrrolidine motif is valuable in designing inhibitors for enzymes like kinases and proteases.
• Ligand Synthesis for Drug Discovery: Serves as a precursor for creating novel ligands with potential activity in oncology and neurological disorders.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce fluorinated, sulfonylated amine functionalities.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biochemical and pharmacological assays.

Basic Information

Item	Details
Product Name	1-(5-Fluoropyridin-3-Ylsulfonyl)Pyrrolidin-2-Amine
CAS No.	1250946-83-8
Molecular Formula	C9H12FN3O2S
Molecular Weight	245.28 g/mol
Synonyms	2-Amino-1-[(5-fluoropyridin-3-yl)sulfonyl]pyrrolidine; 1-[(5-Fluoropyridin-3-yl)sulfonyl]-2-pyrrolidinamine; 1-(5-Fluoropyridine-3-sulfonyl)pyrrolidin-2-amine; 5-Fluoro-3-[(2-aminopyrrolidin-1-yl)sulfonyl]pyridine; Pyrrolidin-2-amine, 1-[(5-fluoropyridin-3-yl)sulfonyl]-; 1250946-83-8; 1-(5-Fluoropyridin-3-ylsulfonyl)pyrrolidin-2-amine
EINECS	Contact for details

Quality Control

Every batch of 1-(5-Fluoropyridin-3-Ylsulfonyl)Pyrrolidin-2-Amine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.