Description

4-(4-tert-Butoxycarbonylamino-Cyclohexyl)-Piperazine-1-Carboxylic Acid Benzyl Ester is a sophisticated piperazine derivative and a key protected intermediate in advanced organic synthesis. Its molecular architecture, featuring both Boc (tert-butoxycarbonyl) and Cbz (benzyloxycarbonyl) protecting groups, makes it a critical building block for constructing complex nitrogen-containing scaffolds. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a versatile precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Peptidomimetic Chemistry: Used to introduce constrained cyclohexyl-piperazine motifs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries via parallel and combinatorial chemistry in high-throughput screening campaigns.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that require specific nitrogen heterocycle frameworks.
• Chemical Biology Probe Development: Facilitates the creation of molecular probes to study enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, multi-gram to kilogram quantities.

Basic Information

Product Name	4-(4-tert-Butoxycarbonylamino-Cyclohexyl)-Piperazine-1-Carboxylic Acid Benzyl Ester
CAS No.	1248730-88-2
Molecular Formula	C23H35N3O4
Molecular Weight	417.55 g/mol
Synonyms	1-Boc-4-(4-CBZ-amino-cyclohexyl)piperazine; 4-(4-((tert-Butoxycarbonyl)amino)cyclohexyl)piperazine-1-carboxylic acid benzyl ester; Benzyl 4-[4-[(tert-butoxycarbonyl)amino]cyclohexyl]piperazine-1-carboxylate; N-Boc-1-CBZ-cis-4-aminocyclohexylpiperazine; 1-N-Boc-4-N-CBZ-4-aminocyclohexylpiperazine; 4-(4-(Boc-amino)cyclohexyl)-1-(Cbz)piperazine; (cis/trans)-4-(4-(tert-Butoxycarbonylamino)cyclohexyl)piperazine-1-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Every batch of our 4-(4-tert-Butoxycarbonylamino-Cyclohexyl)-Piperazine-1-Carboxylic Acid Benzyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via techniques such as HPLC, NMR, and MS. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.