Description

Ethyl 2,2-Difluoro-2-(Pyridin-3-Yl)Acetate CAS NO 1247716-64-8 is a high-value fluorinated pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both a difluoroacetate ester and a pyridinyl moiety, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated pyridine scaffolds to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides where the difluoromethyl group can improve lipophilicity and biological activity.
• Material Science: Building block for creating specialty polymers, liquid crystals, or organic electronic materials that benefit from fluorine's unique electronic properties.
• Chemical Synthesis: Versatile reagent for introducing the 2,2-difluoro-2-(pyridin-3-yl)acetyl fragment via ester hydrolysis or transesterification reactions in medicinal and process chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for client projects.

Basic Information

Item	Details
Product Name	Ethyl 2,2-Difluoro-2-(Pyridin-3-Yl)Acetate
CAS No.	1247716-64-8
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3-Pyridinyl)Acetate; 2,2-Difluoro-2-(3-Pyridinyl)Acetic Acid Ethyl Ester; 3-Pyridyl(difluoro)Acetic Acid Ethyl Ester; Ethyl 3-Pyridyldifluoroacetate; Ethyl α,α-Difluoro-3-Pyridineacetate; 1247716-64-8; Acetic acid, 2,2-difluoro-2-(3-pyridinyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2,2-Difluoro-2-(Pyridin-3-Yl)Acetate is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and consistency for your critical R&D and scale-up processes. Our quality commitment supports compliance with ISO standards and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.