Description

Evogliptin Hydrochloride is a high-purity, small-molecule pharmaceutical active ingredient. It serves as a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, a critical mechanism for regulating blood glucose levels. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing advanced treatments for type 2 diabetes mellitus.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of anti-diabetic medications.
• Pharmaceutical Intermediates for the synthesis of more complex DPP-4 inhibitor drug candidates.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research for studying DPP-4 enzyme kinetics and diabetes-related metabolic pathways.
• Pre-clinical and Clinical Trial Material for new drug development programs.
• Generic Drug Manufacturing for producing bioequivalent versions of branded DPP-4 inhibitor therapies.

Basic Information

Product Name	Evogliptin Hydrochloride
CAS No.	1246960-27-9
Molecular Formula	C23H30N2O4 • HCl
Molecular Weight	442.96 g/mol
Synonyms	Evogliptin HCl; (R)-4-[(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(tert-butoxymethyl)piperazin-2-one hydrochloride; DA-1229 Hydrochloride; 1-(((3R,5R)-5-((R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl)-2-oxo-1-(2,2,2-trifluoroethyl)piperidin-3-yl)methyl)-5-(2-ethoxybenzyl)pyrimidine-2,4(1H,3H)-dione hydrochloride; (3R)-3-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]oxymethyl]-1-(2,2,2-trifluoroethyl)-4-piperidinone hydrochloride
EINECS	Contact for details

Quality Control

Our Evogliptin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical standards, including identity, potency, and impurity profile verification. A Certificate of Analysis (COA) detailing specifications such as assay (HPLC), related substances, residual solvents, and heavy metals is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.