Description

(S)-2-(Piperazin-2-Yl)Ethanol Dihydrochloride CAS NO 1246651-15-9 is a high-purity chiral piperazine derivative, specifically the (S)-enantiomer of 2-(piperazin-2-yl)ethanol in its stable dihydrochloride salt form. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules and APIs.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries and exploring structure-activity relationships (SAR).
• Ligand Synthesis: Used in the preparation of chiral ligands for asymmetric catalysis.
• Bioconjugation: The ethanol moiety provides a handle for linking to other molecules or surfaces in bioconjugate chemistry.
• Chemical Biology Probes: Acts as a scaffold for developing probes to study biological pathways and enzyme functions.
• Preclinical Development: Supports early-stage drug discovery and development processes requiring high-purity, enantiomerically pure intermediates.

Basic Information

Product Name	(S)-2-(Piperazin-2-Yl)Ethanol Dihydrochloride
CAS No.	1246651-15-9
Molecular Formula	C6H14N2O·2HCl
Molecular Weight	211.11 g/mol
Synonyms	(S)-2-(2-Piperazinyl)ethanol dihydrochloride; (S)-2-Piperazin-2-ylethanol dihydrochloride; (S)-2-(Piperazin-2-yl)ethan-1-ol dihydrochloride; (2S)-2-(Piperazin-2-yl)ethanol dihydrochloride; (S)-2-Hydroxyethylpiperazine dihydrochloride; (S)-HEP dihydrochloride; (S)-2-Piperazinylethanol dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-(Piperazin-2-Yl)Ethanol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.