Description

n-Lauroyl-1-Deoxysphingosine (M18:1/12:0) is a synthetic, defined sphingolipid analog where a lauroyl (C12:0) fatty acid chain is amide-linked to a 1-deoxysphingosine (sphinganine) backbone. This compound is a critical research-grade biochemical tool for investigating the structure, function, and metabolism of sphingolipids, which are essential components of cell membranes and key signaling molecules. It is primarily utilized by researchers and developers in the life sciences, pharmaceutical R&D, and biotechnology sectors for studies in lipidomics, cell biology, and metabolic pathway analysis.

Application

• Biochemical Research: As a defined standard and substrate for studying sphingolipid metabolism, enzymatic activity (e.g., ceramide synthases), and intracellular signaling pathways.
• Lipidomics & Analytical Standards: Use as a high-purity internal standard or reference compound in mass spectrometry (LC-MS, GC-MS) for the accurate quantification of complex biological lipid samples.
• Cell Biology Studies: Investigation of the role of specific sphingolipid species in cell membrane dynamics, apoptosis, autophagy, and cellular stress responses.
• Pharmaceutical Development: Exploration in drug discovery programs targeting sphingolipid-related diseases, such as metabolic disorders, neurodegenerative conditions, and cancer.
• Enzyme Assay Development: Serving as a specific substrate for in vitro assays to characterize the kinetics and inhibition of enzymes involved in the sphingolipid biosynthetic pathway.

Basic Information

Product Name	n-Lauroyl-1-Deoxysphingosine (M18:1/12:0)
CAS No.	1246298-54-3
Molecular Formula	C30H59NO3
Molecular Weight	481.80 g/mol
Synonyms	N-[(2S,3R)-1,3-Dihydroxyoctadecan-2-yl]dodecanamide; Lauroylsphinganine; D-erythro-C18 Dihydroceramide (d18:0/12:0); N-Dodecanoylsphinganine; 1-Deoxysphingosine C12:0; Ceramide(d18:0/12:0); (2S,3R)-2-(Dodecanoylamino)octadecane-1,3-diol
EINECS	Contact for details

Quality Control

Our n-Lauroyl-1-Deoxysphingosine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP principles where applicable to support our commitment to reliable and traceable supply for the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.