Description

3,5-Didemethoxy Piperlongumine is a synthetic derivative of the natural alkaloid piperlongumine, characterized by the removal of two methoxy groups from its core structure. This modification enhances its bioavailability and alters its pharmacological profile, making it a valuable research-grade biochemical for studying cellular pathways. It is primarily utilized by pharmaceutical R&D and academic research institutions investigating oncology, inflammation, and metabolic disorders.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the discovery and development of novel therapeutic agents targeting cancer and inflammatory diseases.
• Biochemical Research: Used as a potent tool compound in in vitro and cell-based assays to study mechanisms of apoptosis, oxidative stress, and signal transduction pathways.
• Academic Studies: Employed in university and institutional labs for fundamental research into the structure-activity relationships (SAR) of piperlongumine analogs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3,5-Didemethoxy Piperlongumine
CAS No.	1246095-66-8
Molecular Formula	C15H15NO3
Molecular Weight	257.29 g/mol
Synonyms	(E)-3-(3,5-Dihydroxyphenyl)-1-(5-oxo-2,5-dihydrofuran-3-yl)prop-2-en-1-one; 3,5-Dihydroxypiperlongumine; Desmethoxypiperlongumine; Piperlongumine Dimerhoxy-Free Analog; PL Dimerhoxy-Free
EINECS	Contact for details

Quality Control

Our 3,5-Didemethoxy Piperlongumine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications suitable for research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.