Description

n-(5-Bromo-2-Cyanopyridin-3-Yl)Pivalamide is a high-purity, multi-functional pyridine derivative building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of complex molecules, offering a unique combination of a bromo substituent for cross-coupling reactions and a cyano group for further functionalization. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a precursor for functionalized ligands and monomers in the creation of advanced polymers and coordination complexes.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form complex biaryl structures.
• Chemical Biology: Utilized as a probe or linker in bioconjugation chemistry and the development of molecular tools.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialty chemicals and complex organic molecules.

Basic Information

Product Name	n-(5-Bromo-2-Cyanopyridin-3-Yl)Pivalamide
CAS No.	1246088-44-7
Molecular Formula	C11H12BrN3O
Molecular Weight	282.14 g/mol
Synonyms	5-Bromo-3-(pivalamido)picolinonitrile; 3-Acetamido-5-bromo-2-cyanopyridine (pivaloyl variant); Pivalamide, N-(5-bromo-2-cyano-3-pyridinyl)-; 5-Bromo-2-cyano-N-(2,2-dimethylpropanoyl)pyridin-3-amine; 3-[(2,2-Dimethylpropanoyl)amino]-5-bromopyridine-2-carbonitrile; 5-Bromo-3-(2,2-dimethylpropanamido)picolinonitrile; Tert-butylcarboxamide derivative of 5-bromo-2-cyanopyridin-3-amine
EINECS	Contact for details

Quality Control

Our n-(5-Bromo-2-Cyanopyridin-3-Yl)Pivalamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality assurance supports your R&D and scale-up processes with reliable, consistent material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.