Description

5-Bromo-1-(Phenylsulfonyl)-1H-Pyrrolo-[2,3-B]Pyridine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound serves as a critical building block for the synthesis of novel, biologically active molecules, particularly in the development of kinase inhibitors and other targeted therapies. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drugs targeting various disease pathways.
• Kinase Inhibitor Development: Used as a core scaffold or derivatization point for creating potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize drug candidate potency and pharmacokinetic properties.
• Process Chemistry & Scale-Up: Serves as a critical material for route scouting, optimization, and pilot-scale production of active pharmaceutical ingredients (APIs).
• Biochemical Probe Synthesis: Utilized to create tool compounds for investigating biological mechanisms and target validation in early-stage research.

Basic Information

Product Name	5-Bromo-1-(Phenylsulfonyl)-1H-Pyrrolo-[2,3-B]Pyridine-2-Carboxylic Acid
CAS No.	1246088-41-4
Molecular Formula	C₁₈H₁₁BrN₂O₄S
Molecular Weight	431.26 g/mol
Synonyms	5-Bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-bromo-1-(phenylsulfonyl)-; 1246088-41-4; 5-Bromo-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(Phenylsulfonyl)-1H-Pyrrolo-[2,3-B]Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.