Description

5-Bromo-2-Ethyl-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a halogenated pyrrolopyridine core protected by a triisopropylsilyl (TIPS) group. This compound is specifically engineered for use in complex multi-step synthesis, offering a critical building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used as a building block for developing novel herbicides, fungicides, and insecticides with specific modes of action.
• Material Science: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its fused heterocyclic structure.
• Chemical Biology: Employed in the design and synthesis of molecular probes and labeled compounds for biological target identification and validation.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of complex target molecules in pilot plants and manufacturing.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and novel heterocycle construction in academic and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	5-Bromo-2-Ethyl-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1246088-36-7
Molecular Formula	C20H31BrN2Si
Molecular Weight	407.47 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-bromo-2-ethyl-1-(triisopropylsilyl)-; 5-Bromo-2-ethyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-2-ethyl-1-(triisopropylsilyl)pyrrolo[2,3-b]pyridine; 2-Ethyl-5-bromo-1-triisopropylsilylpyrrolo[2,3-b]pyridine; TIPS-protected 5-bromo-2-ethylpyrrolo[2,3-b]pyridine; 5-Br-2-Et-1-TIPS-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Ethyl-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption or contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.