Description

6-Chloro-5-(Trifluoromethyl)Nicotinonitrile CAS NO 1245915-29-0 is a high-value, multi-functional heterocyclic building block featuring a chloropyridine core substituted with a trifluoromethyl group and a nitrile moiety. This compound is strategically important for its role in facilitating structure-activity relationship (SAR) studies and enabling the synthesis of complex molecules with enhanced biological and physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-withdrawing substituents.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	6-Chloro-5-(Trifluoromethyl)Nicotinonitrile
CAS No.	1245915-29-0
Molecular Formula	C7H2ClF3N2
Molecular Weight	206.55 g/mol
Synonyms	6-Chloro-5-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-6-chloro-5-(trifluoromethyl)pyridine; 6-Chloro-5-trifluoromethylnicotinonitrile; 5-(Trifluoromethyl)-6-chloronicotinonitrile; 2-Chloro-3-cyano-5-(trifluoromethyl)pyridine; 6-Chloro-5-(trifluoromethyl)-3-pyridinecarbonitrile; Nicotinonitrile, 6-chloro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-5-(Trifluoromethyl)Nicotinonitrile is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.