Description

5-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridine is a high-value, heterocyclic organic compound featuring a fused pyrazolopyridine core substituted with a trifluoromethyl group. This structure is critical for its role as a versatile and potent building block in modern pharmaceutical discovery and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel active molecules. The compound's unique electronic and steric properties, imparted by the trifluoromethyl group, make it essential for modulating the bioavailability, metabolic stability, and binding affinity of target candidates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small-molecule drugs targeting kinases, receptors, and enzymes, particularly in oncology and CNS disease research.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances lipophilicity and biological activity.
• Material Science Precursor: Serves as a specialized ligand or functional group in the design of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Employed in the creation of molecular probes and tags for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	5-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridine
CAS No.	1245914-99-1
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	5-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine, 5-(trifluoromethyl)-; 5-Trifluoromethyl-1H-pyrazolo[3,4-b]pyridine; 5-Trifluoromethylpyrazolo[3,4-b]pyridine; 5-CF3-1H-pyrazolo[3,4-b]pyridine; 5-(Trifluoromethyl)pyrazolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support compliance with global regulatory frameworks, and custom purity grades (e.g., >98%, >99%) are available to suit specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.